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The benefits of intentional weight loss can be very significant. In addition to the directly physiological changes, improvements in disease risk markers, there is also an improvement in comorbid disease control and, not to be forgotten, the very profound psychological benefits that can follow.In 1997, Jung published estimates of the benefits of intentional weight loss. He estimated the effects of 10% body weight loss that being an average of 10-kg weight loss in subjects averaging 100-kg in weight. Jung’s study also recognized that a 10% loss of bodyweight produced a >50% decrease in the risk of developing type 2 diabetes, a fall in fasting glucose levels of between 30 and 50%, and a 15% decrease in HbA1c. Clinical experience shows that even a 5% bodyweight loss can produce quite profound benefits and many patients will express subjective improvements of decreased breathlessness’, less weight-bearing joint pain, more energy and a more positive outlook.To achieve these long-term health benefits, initial weight loss has to be maintained. In developing any weight-loss programme the emphasis must be on long-term weight management, and this has proven to be the greater challenge over early weight-loss success. The long-term prospects for those who are able to maintain their weight loss can be very significant. Hypertensive patients might be able to manage their hypertension and find they no longer require a prescription of antihypertensive agents. Type 1 diabetics might be able to reduce their insulin dosage levels, type 2 diabetics might decrease and even remove their need for hypoglycaemic agents. Additionally, they are highly likely to delay the onset of cardiovascular disease and to improve their life expectancy.However, many experts would emphasize that the improvements are best seen as a means of delaying disease and long-term monitoring of those at risk is essential. Recent research would suggest that those who are obese at the age of 40, despite long-term weight loss, do carry a decrease in life expectancy of approximately 3 years.*63/312/5*
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